With lifestyle changes, new pharmacological agents may have a promising difference in results, the authors say.

When lifestyle changes, diet and exercise fail, weight-loss medications and surgeries can be effective in preventing and treating obesity-related hypertension, say experts from the American Heart Association (AHA).

“It is obvious that diet and exercise are really the cornerstones. “The statement was not intended to imply that medication or surgery should replace diet and exercise,” Michael Hall, MD (MD, of the University of Mississippi Medical Center, acks exon), told TCTMD. “But we know that only a handful of competent people are either operated on or treated. “We are hopeful that doctors are aware of the number one risks of obesity-related hypertension, that we will have to wait until patients develop target organ damage, and that we want to treat upstream.”

The document was published before its online publication on Monday Hypertension, follows the more general AHA guideline statements that apply to: physical activity, diet:, և: weight control. It highlights recently published data on obesity, including studies DASH dietas well as new medical therapies such as glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide (Ozempich). The Writing Committee also quotes GATEWAY: Test results that show the safety and effectiveness of bariatric surgery in lowering blood pressure.

“Given the growing prevalence of obesity և the fact that hypertension is strongly associated with obesity և their impact on cardiovascular disease, we thought it was a good time to refresh what we know about diet և other than exercise,” Hall explained. .

He warned against seeking “quick fixes” for drugs and surgeries, but said they were appropriate after a qualified patient had already worked hard to change their lifestyle. According to Holly, while diet and exercise “work for some, they are difficult to maintain in the long run.” This is where medications and surgery can complement lifestyle changes to better lower blood pressure in the long run.

Commenting on the TCTMD statement, Ph.D., Ph.D. Steven Yurashek (Beth Israel Deaconess Medical Center, Boston, MA), The newspaper “sheds light” on the possibility of the current hypertension epidemic in the United States. “Another key feature with hypertension is that there is a huge focus on health imbalances, so we see sharp differences in the number of people in hypertensive-hypertensive control over different demographic groups,” he said. “For these reasons, it is very difficult, at least in terms of chronic conditions, to ignore the role of hypertension in terms of both the development of cardiovascular disease and health imbalances.”

Yuraschek, who led the above study on the DASH diet, praised the statement, which specifically highlighted the role of obesity in hypertension. “One of the common misconceptions about non-pharmacological interventions to lower blood pressure is that it is either either or we are focusing on lifestyle or taking medication. is: “The two together,” he said. “What is becoming more and more obvious is that you can treat hypertension with medication, but if you are still eating high-sodium foods, still obese or overweight, those medications may be less effective.” :

Many of the newer pharmacological drugs for weight loss are “exciting” for Yurashek, as there have not been many developments in this area until recently. For example, he called semaglutide a “game changer” because it can reduce weight and blood pressure without many side effects. “We can see for the first time really effective, well-tolerated care therapy for weight loss, which I think is quite exciting,” he said.

Until now, weight was not considered a cardiovascular risk factor as high as blood pressure for many doctors, Yurashek noted. “But we know that weight and obesity are prone to high blood pressure and hypertension, so I think the role of obesity may not be distorted.”

He added that the stigma of obesity still plays a role in its treatment. “We do not have such a filter, which is used for high blood pressure, high cholesterol, we are more suited to the concept of treating these other risk factors. And I think now. . . “There is an opportunity for us to actually cure obesity. I think more and more that it is an appropriate strategy.”

Looking forward, Hall said he would like to see more research, especially for children and adults. “We would like to know, if you are starting medication, or if you are successfully losing weight with medication or surgery, before these problems develop, what is the long-term effect of the young person but the patient who is not developing?” he said. “A lot of times we just don’t direct them until they already have the disease, it’s a lot of clinical trials.”

In addition, Yurashek said he would like to see more work on “the pathways that link obesity to cardiovascular disease and injury, so that we can understand them a little more thoroughly, so some biological-mechanical research, especially now with these alternative pharmacological approaches.” There are still many questions about how to optimize the diet to reduce weight and blood pressure, as well as those who contribute to hypertension during pregnancy.